The first place that you should head to, early in the morning on day one, has to be the Colosseum.
Next, it’s time to stroll over to the Roman Forum. If you purchased a combined ticket to the Colosseum you’ll also have access to the Roman Forum and Palatine Hill.
Next, your Rome 3-day itinerary takes you only a 5-minute walk from the Roman Forum to Piazza Venezia, where you can see the Altare della Patria.
After a 12-minute walk you will reach the Pantheon. This is totally a must see on a Rome in 3 days itinerary. This religious building originated as a temple that was built in 27 BC.
The Vatican, with its museums and world famous Sistine Chapel, are going to take more than a few hours to explore.
After you’ve spent time marvelling at the incredible sights of the Vatican, it’s just a short walk to the Castel Sant’Angelo.
From the Castel Sant’Angelo, wander through the historic streets for about 20 minutes until you come across the Trevi Fountain.